HYDROCODONE BITARTRATE 5/325MG (ACETAMINOPHEN)
HYDROCODONE BITARTRATE 5MG/325MG (ACETAMINOPHEN) How does Hydromorphone Hydrochloride tablets work? What are its effects ?
Controlled release hydromorphone belongs to the family of medications called opioid analgesics (analgesic narcotics). It is used to treat chronic pain of high intensity. Hydromorphone Hydrochloride 8mg tablets has an action on the brain that increases the ability to tolerate pain. Controlled release hydromorphone works by gradually releasing the drug into the body to help control pain that requires prolonged or continuous use of an opioid painkiller. HYDROCODONE BITARTRATE 5MG/325MG (ACETAMINOPHEN)
Hydromorphone Hydrochloride tablets is a powerful painkiller that can kill someone who takes this medicine without being prescribed it. HYDROCODONE BITARTRATE 5MG/325MG (ACETAMINOPHEN)
Hydromorphone Hydrochloride tablets is available under various brand names or in different presentations. A specific brand of this medication may not be available in all forms or approved for all conditions mentioned here. In addition, some forms of this medicine may not be used against all conditions mentioned in this article.
Your doctor may have suggested this medicine for a condition not listed in this drug information article. If you have not discussed this with your doctor, or if you are not sure why you are taking this medicine, check it out. Do not stop taking this medicine without first consulting your doctor. HYDROCODONE BITARTRATE 5MG/325MG (ACETAMINOPHEN)
Do not give this medicine to anyone, even someone who has the same symptoms as you. This medication may be harmful to people for whom it has not been prescribed. HYDROCODONE BITARTRATE 5MG/325MG (ACETAMINOPHEN)(ACETAMINOPHEN)
What are the possible side effects of Hydromorph Contin?
Many medications can cause side effects. A side effect is an undesirable response to a drug when taken at normal doses. It can be mild or severe, temporary or permanent.
The side effects listed below are not felt by everyone who takes this medicine. If you are worried about side effects, discuss the risks and benefits of this medicine with your doctor. HYDROCODONE BITARTRATE 5MG/325MG (ACETAMINOPHEN)
At least 1% of people taking this medicine have reported the following side effects. A lot of these side effects can be taken care of and a few can go away on their own with time. HYDROCODONE BITARTRATE 5MG/325MG (ACETAMINOPHEN)
Consult your doctor if you experience these side effects and if they are serious or bothersome. Your pharmacist may be able to give you advice on what to do if these side effects occur: a drowsiness;
dizziness, lightheadedness, or feeling unconscious
dryness of the mouth
Hydrocodone Bitartrate and Acetaminophen is available in tablet form for oral administration.
Hydrocodone bitartrate is an opioid analgesic and occurs as fine, white crystals or as a crystalline powder. It is affected by light. The chemical name is 4, 5α-epoxy-3-methoxy-17-methylmorphinan-6-one tartrate (1:1) hydrate (2:5). It has the following structural formula
Acetaminophen, 4´-hydroxyacetanilide, a slightly bitter, white, odorless, crystalline powder, is a non-opiate, non-salicylate analgesic and antipyretic. It has the following structural formula.
Gastrointestinal Tract and Other Smooth Muscle Effect
Hydrocodone causes a reduction in motility associated with an increase in smooth muscle tone in the antrum of the stomach and duodenum. Digestion of food in the small intestine is delayed and propulsive contractions are decreased. Propulsive peristaltic waves in the colon are decreased, while tone may be increased to the point of spasm, resulting in constipation. Other opioid-induced effects may include a reduction in biliary and pancreatic secretions, spasm of sphincter of Oddi, and transient elevations in serum amylase.
Cardiovascular System Effect
Hydrocodone produces peripheral vasodilation which may result in orthostatic hypotension or syncope. Manifestations of histamine release and/or peripheral vasodilation may include pruritus, flushing, red eyes, sweating, and/or orthostatic hypotension.
Endocrine System Effect
Opioids inhibit the secretion of adrenocorticotropic hormone (ACTH), cortisol, and luteinizing hormone (LH) in humans [see ADVERSE REACTIONS ]. They also stimulate prolactin, growth hormone (GH) secretion, and pancreatic secretion of insulin and glucagon. HYDROCODONE BITARTRATE 5MG/325MG (ACETAMINOPHEN)
Chronic use of opioids may influence the hypothalamic-pituitary-gonadal axis, leading to androgen deficiency that may manifest as symptoms as low libido, impotence, erectile dysfunction, amenorrhea, or infertility. The causal role of opioids in the syndrome of hypogonadism is unknown because the various medical, physical, lifestyle, and psychological stressors that may influence gonadal hormone levels have not been adequately controlled for in studies conducted to date see ADVERSE REACTIONS
Immune System Effect
Opioids have been shown to have a variety of effects on components of the immune system. The clinical significance of these findings is unknown. Overall, the effects of opioids appear to be modestly immunosuppressive. HYDROCODONE BITARTRATE 5MG/325MG (ACETAMINOPHEN)
Concentration Efficacy Relationships
The minimum effective analgesic concentration will vary widely among patients, especially among patients who have been previously treated with potent agonist opioids. The minimum effective analgesic concentration of 4 hydrocodone for any individual patient may increase over time due to an increase in pain, the development of a new pain syndrome, and/or the development of analgesic tolerance see DOSAGE AND ADMINISTRATION. HYDROCODONE BITARTRATE 5MG/325MG (ACETAMINOPHEN)
Use Hydrocodone When Pregnant
Prolonged use of Hydrocodone Bitartrate and Acetaminophen Tablets during pregnancy can result in withdrawal in the neonate. Neonatal opioid withdrawal syndrome, unlike opioid withdrawal syndrome in adults, may be life-threatening if not recognized and treated, and requires management according to protocols developed by neonatology experts. Observe newborns for signs of neonatal opioid withdrawal syndrome and manage accordingly. Advise pregnant women using opioids for a prolonged period of the risk of neonatal opioid withdrawal syndrome and ensure that appropriate treatment will be available.